A Primate's Memoir Mobi 12

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This is the subject of my book. I begin by trying to clarify the meaning of the nebulous concept of stress and to teach, with a minimum of pain, how various hormones and parts of the brain are mobilized in response to stress. I then focus on the links between stress and increased risk for certain types of disease, going, chapter by chapter, through the effects of stress on the circulatory system, on energy storage, on growth, reproduction, the immune system, and so on. Next I describe how the aging process may be influenced by the amount of stress experienced over a lifetime. I then examine the link between stress and the most common and arguably most crippling of psychiatric disorders, major depression. As part of updating the material for this third edition, I have added two new chapters: one on the interactions between stress and sleep, and one on what stress has to do with addiction. In addition, of the chapters that appeared in the previous edition, I rewrote about a third to half of the material.

And sometimes we humans can be stressed by things that simply make no sense to zebras or lions. It is not a general mammalian trait to become anxious about mortgages or the Internal Revenue Service, about public speaking or fears of what you will say in a job interview, about the inevitability of death. Our human experience is replete with psychological stressors, a far cry from the physical world of hunger, injury, blood loss, or temperature extremes. When we activate the stress-response out of fear of something that turns out to be real, we congratulate ourselves that this cognitive skill allows us to mobilize our defenses early. And these anticipatory defenses can be quite protective, in that a lot of what the stress-response is about is preparative. But when we get into a physiological uproar and activate the stress-response for no reason at all, or over something we cannot do anything about, we call it things like anxiety, neurosis, paranoia, or needless hostility.

If your body has mobilized all that glucose, it also needs to deliver it to the critical muscles as rapidly as possible. Heart rate, blood pressure, and breathing rate increase, all to transport nutrients and oxygen at greater rates.

Selye, with his ulcerated rats, wrestled with this puzzle and came up with an answer that was sufficiently wrong that it is generally thought to have cost him a Nobel Prize for all his other work. He developed a three-part view of how the stress-response worked. In the initial (alarm) stage a stressor is noted; metaphorical alarms go off in your head, telling you that you are hemorrhaging, too cold, low on blood sugar, or whatever. The second stage (adaptation, or resistance) comes with the successful mobilization of the stress-response system and the reattainment of allostatic balance.

With this framework in mind, we can now begin the task of understanding the individual steps in this system. Chapter 2 introduces the hormones and brain systems involved in the stress-response: which ones are activated during stress, which ones are inhibited This leads the way to chapters 3 through 10, which examine the individual systems of your body that are affected. How do those hormones enhance cardiovascular tone during stress, and how does chronic stress cause heart disease (chapter 3) How do those hormones and neural systems mobilize energy during stress, and how does too much stress cause energetic diseases (chapter 4) And so on. Chapter 11 examines the interactions between stress and sleep, focusing on the vicious circle of how stress can disrupt sleep and how sleep deprivation is a stressor. chapter 12 examines the role of stress in the aging process and the disturbing recent findings that sustained exposure to certain of the hormones secreted during stress may actually accelerate the aging of the brain. As will be seen, these processes are often more complicated and subtle than they may seem from the simple picture presented in this chapter. 1e1e36bf2d